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Agarose Gel Electrophoresis of RNA


A new study from RNA

Recently, a research finds that genetic variants that reduce the editing levels of double-stranded RNA are associated with autoimmune and immune-mediated conditions.

RNA molecules can undergo modifications. For example, nucleotides may be inserted, deleted, or changed. One of the most common edits, which new research shows plays an important role in the onset of inflammatory disease, is the transformation of the nucleotide adenosine into inosine within a double-stranded RNA. A study was published on August 3 in Nature reveals that genetic variants that dampen this specific modification are associated with an increased risk of autoimmune and immune-mediated inflammatory disorders such as psoriasis, inflammatory bowel disease, and type 1 diabetes. The authors propose that a sensor protein likely mistakes these less-edited RNAs for foreign molecules, triggering an inflammatory response.

Molecular biologist thought that its really a major breakthrough, and found  it “really striking” how important RNA editing appears to be for inflammatory diseases, compared to gene expression or splicing.

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It is really a great research. And as an electrophoresis products sales, I am curious about what is RNA, and how the scientists analysis RNA by electrophoresis? It is a really very professional and unacquainted knowledge for me but still it is fun to explore it.

What is RNA?

RNA, short for Ribonucleic acid, a nucleic acid present in all living cells. Unlike DNA, RNA is a most often single-stranded. Its principal role is to act as a messenger carrying instructions from DNA for controlling the synthesis of proteins, although in some viruses RNA rather than DNA carries the genetic information.

Agarose Gel Electrophoresis of RNA

People can assess the quality of RNA by gel electrophoresis.

Beijing Liuyi Biotechnology Co.Ltd, a professional manufacturer focusing on electrophoresis products over 50 years, offers a range of electrophoresis tanks (chambers/cells) for gel electrophoresis, such as horizontal electrophoresis tanks (chambers/cells) for agarose gel electrophoresis, and vertical electrophoresis tanks (chambers/cells) for protein gel electrophoresis. Meanwhile, it also provides different types of electrophoresis power supply, cabinet dark box analyzer and UV transilluminator. You can choose Beijing Liuyis electrophoresis tanks (chambers/cells) to measure the molecular weight of RNA and to separate RNA of different sizes for your lab.

Here we will introduce one type of horizontal electrophoresis tank (chamber/cell) model DYCP-31DN from our 31 series products.

31DN

 

DYCP-31DN is a small size horizontal electrophoresis tank(chamber/cell) for measuring the molecular weight of RNA or DNA and to separate them.

Dimension (LxWxH)

310×150×120mm

Gel Size (LxW)

60×60mm

60×120mm

120×60mm

120×120mm

Comb

2+3 wells (2.0mm)

6+13 wells, 8+18 wells

11+25 wells

Comb Thickness

1.0mm, 1.5mm and 2.0mm

Number of Samples

2-100

Buffer Volume

650 ml

Weight

1.0kg

It has four different gel trays to make 4 different sizes of gels. The unique design for combs meet variety requirements for samples wells. The buffer volume is around 650ml. Less amount of buffer solution, but more easy operation and economical to use. It is one of our hot sales products. It deserves your choose.

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Beijing Liuyi Biotechnology Co.Ltd also can provide OEM gel tanks. If you need custom-made electrophoresis tank/cell/chamber, Liuyi Biotechnology can provide you with excellent OEM service.

The Liuyi brand has more than 50-year history in China and the company can provide stable and high-quality products all around the world. Through years of development, it is worthy of your choice!

For more information about us, please contact us by email sales@ly.com.cn or sales01@ly.com.cn.

References for Agarose Gel Electrophoresis of RNA

1. Deficient RNA Editing Implicated in Inflammatory Disease by Alejandra Manjarrez